There is a one-to-one relationship between objects in MAPI and the objects presented to Python. MAPI provides two main entrypoints in a classfactory-pattern to obtain references to the top-level objects.
These functions are:
MAPIAdminProfiles()
MAPILogonEx()
These functions can be used to create and manage MAPI profiles, and log on to one of those profiles, respectively. Each call returns a top-level object which can be used to subsequently open other objects:
import MAPI
profadmin = MAPI.MAPIAdminProfiles(0)
profadmin.CreateProfile('profile','password', 0, 0)
...
session = MAPI.MAPILogonEx(0, 'profile','password', 0)
session.GetMsgStoresTable(0)